“Brexit means Brexit” is the strong and clear declaration from the UK’s new prime minister, Theresa May. Unfortunately, however, no-one knows precisely what that means at present. The implications—some positive and some negative—are likely to be far-reaching in many sectors. Being very highly regulated, the life sciences sector will undoubtedly feel the effects of the UK’s exit from Europe in the coming years, but what impact might it have on orphan drugs?